Alignment of alleles: Atlantic cod (Gadus morhua) IGHV3S28

When several alleles are shown, the nucleotide mutations and amino acid changes for a given codon are indicated in red letters. These polymorphic mutations are reported in Tables of alleles.
Dashes indicate identical nucleotides. Dots indicate gaps according to the IMGT unique numbering. Blanks indicate partial sequences (blanks at the 5' and/or 3' end).

Germline genomic sequences are needed to confirm if the nucleotide substitutions result from somatic mutations or correspond to allelic polymorphisms.

                                  1   2   3   4   5   6   7   8   9  10  11  12  13  14  15  16  17  18  19  20
                                 C   L   Q   L   T   Q   P   E   S       L   T   V   R   P   G   Q   P   L   T
  AJ279394,IGHV3S28*01, 8       TGT TTA CAG CTT ACT CAG CCC GAG TCT ... CTG ACT GTC CGA CCT GGT CAA CCT CTG ACC

  AJ274744,IGHV3S28*02, 12-06   --- --- --- --- --- --- --- --- --- ... --- --- --- --- --- --- --- --- --- ---

                                                        ___________________CDR1-IMGT____________________
                                 21  22  23  24  25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
                                 I   R   C   Q   V   S   Y   A   V   S   G   H   W                       T   A
  AJ279394,IGHV3S28*01, 8       ATC CGC TGT CAG GTC TCT TAT GCT GTT AGT GGC CAC TGG ... ... ... ... ... ACA GCT

  AJ274744,IGHV3S28*02, 12-06   --- --- --- --- --- --- --- --- --- --- --- --- --- ... ... ... ... ... --- ---

                                                                                            _______________CDR2-
                                 41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56  57  58  59  60 
                                 W   I   R   Q   P   E   G   H   A   L   E   W   I   G   R   I   Y   T   G   D
  AJ279394,IGHV3S28*01, 8       TGG ATC AGA CAA CCT GAA GGA CAT GCA CTC GAA TGG ATT GGA CGG ATT TAT ACT GGG GAC
                                                                                         Q  
  AJ274744,IGHV3S28*02, 12-06   --- --- --- --- --- --- --- --- --- --- --- --- --C --- -A- --- --- --- --- ---

                                IMGT________________
                                 61  62  63  64  65  66  67  68  69  70  71  72  73  74  75  76  77  78  79  80
                                 K                   L   M   K   D   S   L   S       S   K   F   S   L   A   V
  AJ279394,IGHV3S28*01, 8       AAA ... ... ... ... CTA ATG AAA GAT TCC CTT AGT ... AGT AAA TTC AGT CTT GCT GTT

  AJ274744,IGHV3S28*02, 12-06   --- ... ... ... ... --- --- --- --- --- --- --- ... --- --- --- --- --- --- ---


                                 81  82  83  84  85  86  87  88  89  90  91  92  93  94  95  96  97  98  99 100
                                 D   G   S   S   N   T   L   T   L   Q   G   Q   N   M   Q   P   G   D   S   A
  AJ279394,IGHV3S28*01, 8       GAC GGC TCC AGT AAT ACA TTA ACT TTG CAA GGG CAA AAC ATG CAG CCT GGA GAC TCA GCT

  AJ274744,IGHV3S28*02, 12-06   --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- --- ---

                                                CDR3-IMGT
                                101 102 103 104 105 106 
                                 V   Y   Y   C   A   S
  AJ279394,IGHV3S28*01, 8       GTG TAT TAC TGT GCC AGC    #c
                                                     R
  AJ274744,IGHV3S28*02, 12-06   --- --- --- --- --- --A    #c
#c: rearranged cDNA

This alignment of allele is automatically generated by Mehdi Yousfi alignment of allele tool.

Created: 21/01/2002
Author: Nathalie Bosc